Modified insulin-like growth factors

Details Modified insulin-like growth factors Modified insulin-like growth factors

C - Chemistry, Metallurgy

07

K

C07K 14/65 (2006.01) A61K 38/30 (2006.01) A61K 47/48 (2006.01) C07K 17/08 (2006.01)

Patent

CA 2190752

Modified forms of insulin-like growth factor (IGF) are provided which demonstrate improved pharmacological and biological properties. These modifications include IGF muteins produced by substituting or adding a cysteine in the amino acid sequence of native IGF as well as such muteins attached to polyethylene glycol (PEG) at the free cysteine site. The present invention further provides methods of making such modified forms. The IGF-PEG conjugates can be formulated into pharmaceutical compositions and used for the therapeutic treatment of IGF associated conditions.

L'invention concerne des formes modifiées du facteur de croissance proche de l'insuline (IGF), qui présentent des propriétés biologiques et pharmacologiques améliorées. Ces modifications comprennent des mutéines de l'IGF produits par substitution ou addition d'une cystéine dans la séquence d'acides aminés de l'IGF natif, ainsi que des mutéines fixées à du polyéthylène-glycol (PEG) au niveau du site de cystéine libre. La présente invention concerne, en outre, des procédés de production de ces formes modifiées. Ces conjugués de PEG-IGF peuvent être formulés pour être transformés en compositions pharmaceutiques et utilisés pour le traitement des conditions associées à l'IGF.

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