C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/21 (2006.01) A61K 38/04 (2006.01) A61K 38/10 (2006.01) A61K 38/21 (2006.01) C07K 7/04 (2006.01) C07K 7/06 (2006.01) C07K 7/08 (2006.01) C07K 14/56 (2006.01) C12N 15/09 (2006.01) G01N 33/53 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2439690
The present invention relates to polypeptides to be administered especially to humans and in particular for therapeutic use. The polypeptides are modified polypeptides whereby the modification results in a reduced propensity for the polypeptide to elicit an immune response upon administration to the human subject. The invention in particular to the modification of human interferon alpha and specifically interferon alpha 2(INF.alpha.2) to result in proteins that are substantially non-immunogenic or less immunogenic than any non- modified counterpart when use in vivo.
La présente invention concerne des polypeptides destinés à une administration à des personnes à des fins thérapeutiques. Ces polypeptides sont des polypeptides modifiés, cette modification entraînant une propension réduite de ce polypeptide à éliciter une réponse immune lors de son administration à un patient. Cette invention concerne en particulier la modification de l'interféron alpha humain et plus spécifiquement de l'interféron alpha 2(INF.alpha.2) de façon à obtenir des protéines sensiblement non immunogènes ou moins immunogènes que d'autres protéines non modifiées dans une utilisation in vivo.
Baker Matthew
Carr Francis J.
Carter Graham
Hanlon Marian
Jones Tim
Fetherstonhaugh & Co.
Merck Patent Gesellschaft Mit Beschraenkter Haftung
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