C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 21/02 (2006.01) A61K 31/712 (2006.01) A61K 31/713 (2006.01) A61K 48/00 (2006.01)
Patent
CA 2522637
The invention relates to iRNA agents, which preferably include a monomer in which the ribose moiety has been replaced by a moiety other than ribose. The inclusion of such a monomer can allow for modulation of a property of the iRNA agent into which it is incorporated, e.g., by using the non-ribose moiety as a point to which a ligand or other entity, e.g., a lipophilic moiety. e.g., cholesterol, is is directly, or indirectly, tethered. The invention also relates to methods of making and using such modified iRNA agents.
L'invention concerne des agents d'ARNi qui comprennent de préférence un monomère dans lequel la fraction ribose a été remplacée par une fraction autre que le ribose. L'inclusion d'un tel monomère permet de moduler une propriété de l'agent d'ARNi dans lequel il est incorporé, p. ex. au moyen de la fraction non-ribose comme point de fixation direct ou indirect d'un ligand ou d'une autre entité, p. ex. une fraction lipophile telle que le cholestérol. L'invention concerne aussi des procédés de fabrication et d'utilisation de ces agents d'ARNi modifiés.
Alnylam Pharmaceuticals Inc.
Smart & Biggar
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