Modified keratinocyte growth factor (kgf) with reduced...

Details Modified keratinocyte growth factor (kgf) with reduced... Modified keratinocyte growth factor (kgf) with reduced...

C - Chemistry, Metallurgy

12

N

C12N 15/18 (2006.01) A61K 9/70 (2006.01) A61K 38/18 (2006.01) A61K 47/02 (2006.01) A61K 47/12 (2006.01) C07K 7/06 (2006.01) C07K 7/08 (2006.01) C07K 14/475 (2006.01) C07K 14/50 (2006.01) C07K 14/54 (2006.01) C07K 16/18 (2006.01) C07K 16/28 (2006.01) C07K 16/30 (2006.01) C07K 16/46 (2006.01) C12N 15/09 (2006.01) A61K 38/00 (2006.01) A61K 38/11 (2006.01) G06F 19/00 (2006.01)

Patent

CA 2437270

The present invention relates to polypeptides to be administered especially to humans and in particular for therapeutic use. The polypeptides are modified polypeptides whereby the modification results in a reduced propensity for the polypeptide to elicit an immune response upon administration to the human subject. The invention in particular relates to the modification of keratinocyte growth factor (KGF) to result in keratinocyte growth factor (KGF) proteins that are substantially non-immunogenic or less immunogenic than any non-modified counterpart when used in vivo.

L'invention concerne des polypeptides à administrer spécialement à des êtres humains et particulièrement destinés à une utilisation thérapeutique. Ces polypeptides sont des polypeptides modifiés, la modification permettant d'obtenir une propension réduite permettant au polypeptide d'éliciter une réponse immune au moment de l'administration chez le sujet humain. L'invention concerne particulièrement la modification du facteur de croissance des kératinocytes (KGF) permettant d'obtenir des protéines d'un facteur de croissance des kératinocytes (KGF) qui sont sensiblement non immunogéniques ou moins immunogéniques qu'une contre-partie non modifiée quelconque dans une utilisation in vivo.

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