Modified ligands for receptor tyrosine kinases

C - Chemistry – Metallurgy – 12 – N

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C12N 15/18 (2006.01) A61K 38/18 (2006.01) C07K 14/475 (2006.01) C07K 14/495 (2006.01) G01N 33/566 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2211099

The invention provides for synthetic ligands that bind to class I receptor tyrosine kinases. The ligands are analogous in structure to naturally occurring ligands. The modified ligands however, have eliminated the mid-sequence (B) domain present in the native ligands and replaced it with a peptide bridge which links the amino (A) and carboxy (C) domains.

L'invention se rapporte à des ligands synthétiques qui se lient aux tyrosines kinases des récepteurs de la classe I. Les ligands sont analogues selon leur structure aux ligands d'origine naturelle. Toutefois, les ligands modifiés ont éliminé le domaine de la séquence intermédiaire (B) présent dans les ligands natifs et l'ont remplacé par un pont peptidique qui se lie aux domaines amino (A) et carboxy (C).

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