Modified macromolecule

C - Chemistry – Metallurgy – 08 – G

Patent

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Details

C08G 81/00 (2006.01) A61K 47/30 (2006.01) A61K 47/48 (2006.01) C08G 69/40 (2006.01) C08G 69/48 (2006.01)

Patent

CA 2636599

The present invention relates to a macromolecule having a controlled terminal group stoichiometry, the macromolecule including a surface layer, at least one subsurface layer and at least two terminal groups including: a first terminal group which is a residue of a pharmaceutically active agent, a derivative thereof or precursor therefor; and a second terminal group selected to modify the pharmacokinetics of the pharmaceutically active agent and/or macromolecule, wherein terminal group stoichiometry refers to the number and type of terminal groups.

La présente invention concerne une macromolécule dont la stAEchiométrie des groupes de terminaison est contrôlée, ladite macromolécule incluant une couche surfacique, au moins une couche subsurfacique et au moins deux groupes de terminaison, parmi lesquels un premier groupe de terminaison qui est un résidu d~un agent actif sur le plan pharmaceutique, un de ses dérivés ou un de des précurseurs, et un second groupe de terminaison choisi pour modifier la pharmacocinétique dudit agent actif sur le plan pharmaceutique et/ou de la macromolécule. Par stAEchiométrie des groupes de terminaison, on entend le nombre et le type de groupes de terminaison.

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