Modified macromolecules and methods of making and using thereof

Details Modified macromolecules and methods of making and using thereof Modified macromolecules and methods of making and using thereof

C - Chemistry, Metallurgy

08

B

C08B 37/00 (2006.01)

Patent

CA 2549295

Described herein are compounds such as macromolecules that have been modified in order to facilitate crosslinking by introduction of at least one hydrazide- reactive group and /or aminooxy-reactive group, and methods of making and using thereof for scar-free wound healing, for delivering bioactive agents or living cells, for preventing adhesion after a surgical procedure or for bone and cartilage repair. The macromolecule can be an oligonucleotide, a necleic acid, a polypeptide, a lipid, a glycoprotein, a glycolipid, a polysaccharide, a protein or a synthetic polymer, preferably a glycosaminoglycan like hyaluronan.

L'invention concerne des composés, tels que des macromolécules, qui ont été modifiés pour faciliter la réticulation, par l'introduction d'au moins un groupe réactif à l'hydrazide et/ou d'un groupe réactif à l'aminooxy, ainsi que des procédés de production et d'utilisation de ces macromolécules dans le traitement sans cicatrice des plaies, dans l'administration d'agents bioactifs ou de cellules vivantes, dans la prévention de l'adhérence suite à un acte chirurgical ou dans la réparation osseuse ou cartilagineuse. La macromolécule selon l'invention peut être un oligonucléotide, un acide nucléique, un polypeptide, un lipide, une glycoprotéine, un glycolipide, un polysaccharide, une protéine ou un polymère synthétique, de préférence un hyaluronane de type glycosaminoglycane.

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