Modified maxadilan protein, its preparation and use, and dna...

Details Modified maxadilan protein, its preparation and use, and dna... Modified maxadilan protein, its preparation and use, and dna...

C - Chemistry, Metallurgy

12

N

C12N 15/62 (2006.01) A61K 38/17 (2006.01) C07K 14/435 (2006.01) C07K 19/00 (2006.01) C12N 15/12 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2167489

A modified maxadilan protein exhibits higher biological activ- ity than native maxadilan from the sand fly Lutzomyia longipalpis. A modified maxadilan fusion protein contains a thrombin cleavage site. This enables the production of the modified maxadilan as a fu- sion protein and recovery of the modified maxadilan after digestion with thrombin. The modified maxadilan is a potent vasodilator.

La protéine dite maxadilane modifiée se caractérise par une activité biologique plus intense que celle de la maxadilane native de la mouche des sables Lutzomyia longipalpis. Une protéine de fusion maxadilane modifiée contient un site de coupure par la thrombine. Ce site permet la production de maxadilane modifiée - une protéine de fusion - et sa récupération après digestion avec la thrombine. La maxadilane modifiée est un puissant vasodilateur.

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