Modified meningococcal polysaccharide conjugate vaccines

C - Chemistry – Metallurgy – 08 – B

Patent

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Details

C08B 37/00 (2006.01) A61K 39/08 (2006.01) A61K 39/095 (2006.01) A61K 39/116 (2006.01) A61K 39/385 (2006.01) A61P 31/04 (2006.01) A61P 37/04 (2006.01) C07K 14/195 (2006.01) C07K 14/22 (2006.01) C07K 16/12 (2006.01)

Patent

CA 2223567

The invention relates to chemically-modified group B polysaccharides of Neisseria meningitidis. The invention also provides vaccines in which the respective modified polysaccharides are conjugated to a protein carrier, and the like. More specifically, the present invention provides novel group B meningococcal unsaturated N-acyl derivative polysaccharides, novel conjugates of the group B meningococcal unsaturated N-acyl derivative polysaccharides, pharmaceutical compositions comprising conjugate molecules of group B meningococcal unsaturated N-acyl derivative polysaccharide fragments covalently bound to proteins, and the use of these compositions as vaccines.

L'invention concerne des polysaccharides de Neisserie meningitidis, du groupe B et chimiquement modifiés, et des vaccins dans lesquels les polysaccharides modifiés respectifs sont conjugués à une protéine porteuse et similaire. Plus spécifiquement, l'invention concerne des polysaccharides méningococciques insaturés nouveaux du groupe B et dérivés de N-acyle, des conjugués nouveaux des polysaccharides méningococciques insaturés du groupe B, dérivés de N-acyle, des compositions pharmaceutiques qui contiennent des molécules conjuguées des fragments des polysaccharides méningococciques insaturés du groupe B, dérivés de N-acyle, ces fragments étant liés par covalence à des protéines, et l'utilisation de ces compositions comme vaccins.

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