Modified morbillivirus v proteins

Details Modified morbillivirus v proteins Modified morbillivirus v proteins

C - Chemistry, Metallurgy

12

N

C12N 15/45 (2006.01) A61K 39/165 (2006.01) C07K 14/115 (2006.01) C07K 14/12 (2006.01) C07K 14/13 (2006.01) C12N 7/00 (2006.01) C12N 7/01 (2006.01)

Patent

CA 2409432

Modified Morbilliviruses having at least one mutation in the region corresponding to amino acids 112-134 of the measles virus V protein are described wherein one or both of amino acids 113 or 114 is mutated. Such modified Morbilliviruses exhibit reduced repression of gene expression. Additional mutations or deletions in other regions of the genome may be included, including in the carboxy-terminal region.

L'invention concerne des morbillivirus modifiés possédant au moins une mutation dans la région correspondant aux acides aminés 112-134 de la protéine V du virus de la rougeole, un ou les deux acides aminés 113 ou 114 ayant subi une mutation. De tels morbillivirus modifiés présentent une répression réduite de l'expression génique. A cela, peuvent s'ajouter des mutations ou des délétions supplémentaires dans d'autres régions du génome, notamment dans la région COOH-terminal.

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