A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/7076 (2006.01) A61K 31/706 (2006.01) A61K 31/7068 (2006.01) A61P 31/00 (2006.01) A61P 31/12 (2006.01) C07H 19/00 (2006.01) C07H 19/048 (2006.01) C07H 19/06 (2006.01) C07H 19/10 (2006.01) C07H 19/16 (2006.01) C07H 19/20 (2006.01) C07H 21/04 (2006.01) C12Q 1/68 (2006.01)
Patent
CA 2426187
The disclosed invention is a composition for and a method of treating a Flaviviridae (including BVDV and HCV), Orthomyxoviridae (including Influenza A and B) or Paramyxoviridae (including RSV) infection, or conditions related to abnormal cellular proliferation, in a host, including animals, and especially humans, using a nucleoside of general formula (I)-(XXIII) or its pharmaceutically acceptable salt or prodrug. This invention also provides an effective process to quantify the viral load, and in particular BVDV, HCV or West Nile Virus load, in a host, using real-time polymerase chain reaction ("TR-PCR"). Additionally, the invention discloses probe molecules that can fluoresce proportionally to the amount of virus present in a sample.
L'invention concerne une composition et une méthode pour traiter une infection <i>Flaviviridae</i> (comprenant BVDV et HCV), <i>Orthomyxoviridae </i> (comprenant influenza A et influenza B) ou <i>Paramyxoviridae</i> (comprenant RSV) infection, ou des états dus à une prolifération cellulaire anormale chez un sujet, qui peut être animal et plus particulièrement humain, en faisant appel à un nucléoside de formule générale (I)-(XXIII) ou à son sel ou à son promédicament pharmaceutiquement acceptable. La présente invention porte également sur un processus efficace pour quantifier la charge virale, en particulier la charge virale BVDV, HCV ou la charge du virus West Nile, chez un sujet, par amplification en chaîne par polymérase en temps réel ("RT-PCR"). En outre, l'invention concerne aussi des molécules sondes qui fluorescent proportionnellement à la quantité de virus présente dans un échantillon.
Stuyver Lieven
Watanabe Kyoichi A.
Mbm Intellectual Property Law Llp
Pharmasset Inc.
Pharmasset Limited
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