Modified nucleotide compounds

Details Modified nucleotide compounds Modified nucleotide compounds

C - Chemistry, Metallurgy

07

H

167/202, 195/1.1

C07H 21/04 (2006.01) A61K 31/715 (2006.01) C07H 21/00 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2029273

ABSTRACT Disclosed is a nuclease resistant nucleotide compound capable of hybridizing with a complementary RNA in a manner which inhibits the function thereof, which modified nucleotide compound includes at least one component selected from the group consisting of MN3M, B(N)xM and M(N)xB wherein N is a phosphodiester-linked modified or unmodified 2'- deoxynucleoside moiety; M is a moiety that confers endonuclease resistance on said component and that contains at least one modified or unmodified nucleic acid base; B is a moiety that confers exonuclease resistance to the terminus to which it is attached; x is an integer of at least 2.

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