Modified oligodeoxyribonucleotides, their preparation and...

C - Chemistry – Metallurgy – 07 – H

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C07H 21/04 (2006.01) A61K 31/70 (2006.01) C07C 317/18 (2006.01) C07H 21/00 (2006.01) C07H 23/00 (2006.01)

Patent

CA 2114355

ABSTRACT Compounds for the treatment or prophylaxis of a viral infection in a mammal, which may be human, are provided. The compounds are oligodeoxyribonucleic acid derivatives, and a novel route to such compounds is also provided together with intermediates of more general utility. The active compounds are of the general formula (1): Image (1) wherein R1, R2 and R3 are hydrogen atoms, alkyl groups, aryl groups as defined, and anthraquinonyl groups as defined; Z is carbon or silicon; or R2, R3 and Z together represent fluorenyl or xanthenyl; R4 is a hydrogen atom, an alkyl group as defined, an aryl group as defined; Y1, Y3 and Y4 are oxygen, sulfur or >NX; Y2 is oxygen, sulfur, >NH, alkylene or phenylene; X is alkylene group as defined; m and n are 0 to 10; and B is an oligodeoxyribonucleotide of chain length 3 to 9; or salts thereof.

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