Modified oligonucleotides

Details Modified oligonucleotides Modified oligonucleotides

C - Chemistry, Metallurgy

07

H

C07H 21/00 (2006.01) A61K 31/70 (2006.01) C07H 23/00 (2006.01)

Patent

CA 2180727

Oligonucleotides of the formula (I): 5'-(U)n-3' in which U is an identical or different radical of a natural or a synthetic nucleoside and n is a number from 2 to 200 comprising at least one structural unit of two consecutive nucleosides wherein one of the nucleotides is substituted in the 2'-position or wherein the nucleotides are substituted differently in their 2'-position, and wherein the backbone is modified.

L'invention se rapporte à des oligonucléotides de la formule (I): 5'-(U)¿n?-3', dans laquelle U représente un radical identique ou différent d'un nucléoside naturel ou synthétique et n représente un nombre compris entre 2 et 200 comportant au moins une unité structurale de deux nucléosides consécutifs. Un des nucléotides est substitué en position 2', ou bien les nucléotides sont substitués différemment en leur position 2', et le squelette est modifié.

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