Modified oligonucleotides for mismatch discrimination

Details Modified oligonucleotides for mismatch discrimination Modified oligonucleotides for mismatch discrimination

C - Chemistry, Metallurgy

07

H

C07H 21/00 (2006.01) A61K 31/7115 (2006.01) C07H 19/06 (2006.01) C07H 19/10 (2006.01) C07H 19/16 (2006.01) C07H 19/20 (2006.01) C12N 15/10 (2006.01) C12P 19/34 (2006.01) C12Q 1/68 (2006.01) C40B 40/06 (2006.01) C40B 50/00 (2006.01) C07B 61/00 (2006.01)

Patent

CA 2401781

Modified oligonucleotides are provided containing bases selected from unsubstituted and 3-substituted pyrazolo[3,4-d]pyrimidines and 5-substituted pyrimidines, and optionally have attached minor groove binders and reporter groups.

La présente invention concerne des oligonucléotides modifiés contenant des bases sélectionnées parmi des pyrazolo[3,4-d]pyrimidines substituées en 3 et non substituées, et qui éventuellement possèdent des liants d'association à la rainure mineure et des groupes rapporteurs.

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