Modified oligonucleotides for telomerase inhibition

Details Modified oligonucleotides for telomerase inhibition Modified oligonucleotides for telomerase inhibition

C - Chemistry, Metallurgy

12

N

C12N 15/115 (2010.01) C12N 15/113 (2010.01) A61K 31/7105 (2006.01) A61P 35/00 (2006.01) C07H 21/00 (2006.01) C12N 15/11 (2006.01) C12N 9/12 (2006.01)

Patent

CA 2536015

Compounds comprising an oligonucleotide moiety covalently linked to a lipid moiety are disclosed. The oligonucleotide moiety comprises a sequence that is complementary to the RNA component of human telomerase. The compounds inhibit telomerase activity in cells with a high potency and have superior cellular uptake characteristics.

L'invention concerne des composés comprenant une fraction oligonucléotidique liée de façon covalente à une fraction lipidique. Cette fraction oligonucléotidique comprend une séquence complémentaire au composé d'ARN de la télomérase humaine. Ces composés inhibent l'activité de la télomérase dans les cellules de façon très efficacité et possèdent des caractéristiques d'absorption cellulaire supérieures.

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