Modified oligonucleotides, their preparation and their use

C - Chemistry – Metallurgy – 07 – H

Patent

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Details

C07H 21/00 (2006.01) A61K 31/70 (2006.01) A61K 31/7052 (2006.01) A61K 31/7084 (2006.01) A61K 31/7088 (2006.01) C07H 19/044 (2006.01) C07H 19/14 (2006.01) C07H 23/00 (2006.01) C12P 19/34 (2006.01) C12Q 1/68 (2006.01) C12Q 1/70 (2006.01)

Patent

CA 2162075

The invention relates to novel modified oligonucleotides which possess at least one substituted 7-deazapurine base and form more stable hybdridization complexes with nucleic acids; to processes for their preparation and to their use as inhibitors of gene expression, as probes for detecting nucleic acids, as aids in molecular biology and as pharmaceuticals or diagnostic agents.

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