Modified papilloma virus l2 protein and vlps formed therefrom

Details Modified papilloma virus l2 protein and vlps formed therefrom Modified papilloma virus l2 protein and vlps formed therefrom

C - Chemistry, Metallurgy

12

N

C12N 15/37 (2006.01) A61K 39/12 (2006.01) A61P 31/20 (2006.01) C07K 14/025 (2006.01) C12N 7/00 (2006.01) C12N 7/04 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2182272

The invention, in one aspect, is directed to a modified papilloma virus L2 protein which does not bind DNA or binds a substantially minimal amount of DNA. The invention is also directed to a method of producing one or more virus-like particles which incorporates a substantially minimal amount of DNA and the virus-like particles produced therefrom.

L'invention se rapporte à une protéine L2 modifiée du virus du papillome, cette protéine ne fixant pas l'ADN ou ne fixant qu'une quantité sensiblement minime d'ADN. L'invention se rapporte également à un procédé de production d'un ou plusieurs viroïdes renfermant une quantité sensiblement minime d'ADN, de même qu'aux viroïdes ainsi obtenus.

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