Modified peptide and peptide libraries with protease...

Details Modified peptide and peptide libraries with protease... Modified peptide and peptide libraries with protease...

C - Chemistry, Metallurgy

07

K

C07K 14/00 (2006.01) A61K 47/48 (2006.01) C07K 1/04 (2006.01) C07K 1/10 (2006.01) C07K 4/00 (2006.01) C07K 5/02 (2006.01) C07K 7/02 (2006.01) C08G 69/00 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2085118

2085118 9119735 PCTABS00008 Peptoids are provided which are polymers comprised of monomer units wherein the monomer units include at least some substitute amino acids and may include conventional amino acids. The peptoids can be synthesized in large numbers so as to provide libraries of peptoids which can be screened in order to isolate peptoids of desired biological activity. Certain peptoids are designed to mimic as closely as possible the activity of known proteins. Other peptoids are designed so as to have greater or lesser activity than known proteins and may be designed so as to block known receptor sites and/or elicit a desired immunogenic response and thereby act as vaccines. A range of different amino acid substitutes are disclosed, as are their methods of synthesis and methods of using such amino acid substitutes in the synthesis of peptoids and peptoid libraries. Methods of screening the libraries in order to obtain desired peptoids of a particular biological activity are also disclosed. The peptoids are preferably linked to a pharmaceutically active drug forming a conjugate with increased binding affinity to a particular biological receptor site.

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