Modified peptide derivatives

Details Modified peptide derivatives Modified peptide derivatives

C - Chemistry, Metallurgy

07

K

C07K 14/54 (2006.01) A61K 47/48 (2006.01) A61K 51/08 (2006.01) C07K 1/13 (2006.01) C07K 14/545 (2006.01) C07K 14/575 (2006.01) C07K 14/695 (2006.01)

Patent

CA 2118595

2118595 9306132 PCTABS00021 A process is disclosed for site-directed chemical modification of peptides and proteins that consists of two steps: (a) selective oxidation of a 2-hydroxyethylamine moiety, -CH(NH2)-CH(OH)-, in the peptide or protein to generate an aldehyde, and (b) reaction of the new aldehyde with a second reagent to form a product in which the native biological properties of the peptide are augmented by new and useful properties conferred by the second reagent. Additionally, the invention pertains to certain specified types of product formed by the above process.

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