Modified peptides and their use for the treatment of...

C - Chemistry – Metallurgy – 07 – K

Patent

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C07K 2/00 (2006.01) A61K 38/02 (2006.01) A61K 38/16 (2006.01) A61K 39/00 (2006.01) C07K 14/00 (2006.01) C07K 14/47 (2006.01)

Patent

CA 2459811

Disclosed herein are a modified peptide, compositions containing the same and their use in the treatment of autoimmune diseases. The modified peptide is provided by a chemical modification of at least one of the several amino acid residues comprising the peptide of sequence RIHMUYSKRSGKPRGYAFIEY (seq ID No : 1). The modification is carried out by phosphorylation, acetylation or methylation, or as a combination thereof.

L'invention concerne un peptide modifié, des compositions le contenant et leur utilisation dans le traitement de maladies auto-immunes. Ce peptide modifié est obtenu par modification chimique d'au moins un des nombreux résidus d'acide aminé comprenant le peptide de séquence RIHMUYSKRSGKPRGYAFIEY (seq ID No : 1). Cette modification est réalisée par phosphorylation, acétylation ou méthylation, ou par une combinaison de ces procédés.

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