Modified peptides yy and conjugates thereof

Details Modified peptides yy and conjugates thereof Modified peptides yy and conjugates thereof

C - Chemistry, Metallurgy

07

K

C07K 2/00 (2006.01) A61K 38/02 (2006.01) A61K 47/42 (2006.01) A61K 47/48 (2006.01) C07K 1/107 (2006.01) C07K 1/113 (2006.01) C07K 14/645 (2006.01)

Patent

CA 2499211

A method for protecting a peptide from peptidase activity in vivo, the peptide being a Peptide YY (PYY) and having a C-terminus and an N-terminus and a C-terminus amino acid and an N-terminus amino acid is described. In the first step of the method, the peptide is modified by attaching a reactive group to the C-terminus amino acid, to the N-terminus amino acid, or to an amino acid located between the N-terminus and the C-terminus, such that the modified peptide is capable of forming a covalent bond in vivo with a reactive functionality on a blood component. In the next step, a covalent bond is formed between the reactive group and a reactive functionality on a blood component to form a peptide-blood component conjugate, thereby protecting said peptide from peptidase activity. The final step of the method involves the analyzing of the stability of the peptide-blood component conjugate to assess the protection of the peptide from peptidase activity.

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