C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/14 (2006.01) C07D 471/04 (2006.01)
Patent
CA 2492540
A method of introducing a second stereogenic center into a tetrahydro-.szlig.- carboline have two stereogenic centers using a modified Pictet-Spengler reaction is disclosed. The method provides a desired cis- or trans-isomer in high yield and purity, and in short processes times.
L'invention concerne un procédé pour introduire un second centre stéréogénique dans une tétrahydro-.szlig.-carboline, afin d'obtenir un composé présentant deux centres stéréogéniques au moyen d'une réaction de Pictet-Spengler. Ledit procédé permet d'obtenir rapidement un isomère cis ou trans voulu, avec un grand rendement et une pureté élevée.
Chelius Erik Christopher
Doecke Christopher William
Martinelli Michael John
Orme Mark W.
Pawlak Joseph Matthew
Lilly Icos Llc
Ridout & Maybee Llp
LandOfFree
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