C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/11 (2006.01) A61K 31/713 (2006.01) C07H 21/02 (2006.01)
Patent
CA 2561868
Methods and compositions for performing RNA interference with decreased off- target effects are provided. The methods and compositions permit effective and efficient applications of RNA interference to applications such as diagnostics and therapeutics through the use of modifications to the siRNA. Uniquely modified siRNAs have been developed that reduce off-target effects incurred in gene-silencing. The modifications comprise 2'-O-alkyl or mismatch modification(s) at specific positions on the sense and/or antisense strands.
Méthodes et compositions permettant d'effectuer l'interférence d'ARN, avec une réduction des effets hors cible. Lesdites méthodes et compositions permettent des applications effectives et efficaces de l'interférence d'ARN dans des applications telles que les diagnostics et les thérapies grâce à l'utilisation de modifications apportées aux ARNsi. Des ARNsi modifiés de manière unique ont été mis au point, lesdits ARNsi réduisant les effets hors cible occasionnés lors du silençage génique. Ces modifications comportent 2'-O-alkyle ou une ou plusieurs modifications de mésappariement à des positions spécifiques sur les brins sens et / ou antisens.
Fedorov Yuriy
Khvorova Anastasia
Leake Devin
Linsley Peter S.
Marshall William
Cassan Maclean
Dharmacon Inc.
Merck & Co. Inc.
Rosetta Inpharmatics Llc
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