Modified polypeptides for enhanced immunogenicity

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/30 (2006.01) A61K 39/015 (2006.01) C07K 14/445 (2006.01) C12N 15/80 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2218987

The invention relates to a recombinant polypeptide showing enhanced immunogenicity, comprising a glycosyl-phosphatidylinositol structure. The polypeptide is for example an antigen, such as a parasite polypeptide, in particular a Plasmodium falciparum polypeptide, such as the circumsporozoite protein (CSP). The invention further relates to a recombinant DNA vector for expressing the polypeptide, methods of inducing an immune response directed to one or more epitopes of the polypeptide, and methods for the production of the modified polypeptides vaccines, comprising the polypeptide.

L'invention concerne un polypeptide recombiné présentant une immunogénicité accrue et comprenant une structure glycosyl-phosphatidylinositol. Ce polypeptide est, par exemple, un antigène, tel qu'un polypeptide parasitaire, notamment un polypeptide de Plasmodium falciparum, tel que la protéine circumsporozoïtique(CSP). L'invention se rapporte en outre à un vecteur d'ADN recombiné destiné à l'expression du polypeptide, à des procédés d'induction d'une réponse immune dirigée contre un ou plusieurs épitopes du polypeptide, ainsi qu'à des procédés de production de vaccins à base de polypeptides modifiés et comprenant le polypeptide de l'invention.

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