Modified pore-forming protein toxins and use thereof

Details Modified pore-forming protein toxins and use thereof Modified pore-forming protein toxins and use thereof

C - Chemistry, Metallurgy

12

N

C12N 15/31 (2006.01) A61K 38/00 (2006.01) A61K 38/16 (2006.01) A61P 35/00 (2006.01) C07K 14/195 (2006.01) C07K 14/33 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12N 15/63 (2006.01)

Patent

CA 2630559

The present invention provides modified pore-forming protein toxins (MPPTs), capable of being used to kill cancer cells. The MPPTs according to the present invention comprise a modification of the naturally occurring activation sequence comprising one or more general cleavage sites, each of which is cleavable by general activating agent, or a plurality of specific cleavage sites, each of which is cleavable by a specific activating agent. Optional further modifications that allow specific targeting of these molecules are also described. These MPPTs may be used to treat cancer.

L'invention porte sur des protéines toxines formatrices de pores (MPPTs) modifiées pouvant être utilisée pour tuer les cellules cancéreuses. Lesdites MPPTs comportent une modification de la séquence d'activation naturelle comprenant un ou plusieurs sites généraux de clivage pouvant être clivés par un agent activateur spécifique. D'autres modifications facultatives permettant le ciblage spécifique de ces molécules sont également décrites. Ces MPPTs peuvent servir à traiter le cancer.

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