Modified prodrug forms of ap/amp

Details Modified prodrug forms of ap/amp Modified prodrug forms of ap/amp

C - Chemistry, Metallurgy

07

D

C07D 213/72 (2006.01) A61K 31/44 (2006.01) A61K 31/47 (2006.01) A61K 31/66 (2006.01) A61K 33/24 (2006.01) A61K 45/06 (2006.01) A61K 47/48 (2006.01) C07F 9/58 (2006.01)

Patent

CA 2423220

The present invention relates to compounds according to the structure of following formula (I), where R is H or CH3; R2 is phosphate which can be free acid or salt; R3 is H, F, C1, Br, I, OCH3, OCF3, CF3 or a C1-C3 alkyl group; R4 is H, F, C1, Br, I, OCH3, OCF3 or CF3; and R5 and R6 are each independently H, F, C1, Br, I, OCH3, OCF3 or CF3, with the proviso that when any two of R3, R4, R5 or R6 are other than H, the other two of R3, R4, R5 or R6 are H which may be used to treat neoplasia, including cancer.

La présente invention concerne des composés présentant la structure (I). Dans cette structure, R est H ou CH¿3 ?; R¿2? est phosphate pouvant être acide libre ou sel ; R¿3? est H, F, Cl, Br, I, OCH¿3?, OCF¿3?, CF¿3? ou un groupe alkyle en C¿1?-C¿3 ;? R¿4? est H, F, Cl, Br, I, OCH¿3?, OCF¿3? ou CF¿3?; et R¿5? et R¿6? sont chacun indépendamment H, F, Cl, Br, I, OCH¿3?, OCF¿3? ou CF¿3?, à condition que lorsque deux groupes quelconques parmi les groupes R¿3?, R¿4?, R¿5? ou R¿6? sont autres que H, les deux autres groupes de l'ensemble R¿3?, R¿4?, R¿5? ou R¿6? sont H. Les composés peuvent être utilisés pour traiter une néoplasie, y compris le cancer.

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