Modified protease inhibitors, process for their preparation,...

C - Chemistry – Metallurgy – 12 – P

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C12P 21/06 (2006.01) C07K 14/815 (2006.01) C12N 9/99 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1230069

Modified protease inhibitors, process for their preparation, and pharmaceutical compositions prepared therefrom Abstract of the Disclosure The invention relates to novel modified eglins B or C, to the preparation thereof, and to pharmaceutical compositions which contain these compounds. Compared with eglin B and C, the modifica- tion consists in a terminal shortening. The compounds of the invention can be prepared e.g. by enzymatic limited proteolysis of eglins or by peptide synthesis.

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