Modified proteases that inhibit complement activation

Details Modified proteases that inhibit complement activation Modified proteases that inhibit complement activation

A - Human Necessities

61

K

A61K 38/48 (2006.01) C12N 5/10 (2006.01) C12N 9/64 (2006.01) C12N 15/62 (2006.01) C12N 15/86 (2006.01)

Patent

CA 2626356

Provided are methods for and compounds for modulating the complement system. In particular, compounds are provided that inhibit complement activation and compounds are provided that promote complement activation. The compounds are therapeutics by virtue of their effects on the complement system. Hence, the compounds that inhibit complement activation can be used for treatment of ischemic and reperfusion disorders, including myocardial infarction and stroke, sepsis, autoimmune diseases, inflammatory diseases and diseases with an inflammatory component, including Alzheimer's Disease and other neurodegenerative disorder.

L~invention concerne des méthodes et des composés qui permettent de moduler le système du complément. En particulier, l'invention concerne des composés qui inhibent l'activation du complément et des composés qui stimulent l'activation du complément. Lesdits composés sont thérapeutiques en raison de leurs effets sur le système du complément. Par conséquent, lesdits composés qui inhibent l'activation du complément peuvent être utilisés pour traiter des troubles ischémiques et de reperfusion, y compris un infarctus du myocarde et un accident cardiovasculaire, une septicémie, des maladies auto-immunes, des maladies inflammatoires et des maladies à composant inflammatoire, y compris la maladie d~Alzheimer et autres troubles neurodégénératifs.

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