C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/62 (2006.01) A61K 38/16 (2006.01) A61K 48/00 (2006.01) A61P 35/00 (2006.01) A61P 37/02 (2006.01) C07K 14/195 (2006.01) C07K 14/33 (2006.01) C07K 14/52 (2006.01) C07K 16/24 (2006.01) C07K 19/00 (2006.01) C12N 15/13 (2006.01) C12N 15/31 (2006.01) C12N 15/63 (2006.01)
Patent
CA 2657946
Pore-forming protein toxins (MPPTs) are provided that comprise a cytokine-receptor targeting unit. The MPPTs according to the present invention are capable of selectively targeting cytokine receptor bearing cells. Optional further modifications that allow specific targeting of these molecules are also described. Methods of using these MPPTs to treat cancer and other diseases are also described.
La présente invention concerne des toxines protéiques formatrices de pores (MPPTs) qui contiennent une unité de ciblage du récepteur des cytokines. Les MPPTs selon la présente invention sont capables de cibler de manière sélective des cellules porteuses du récepteur des cytokines. L'invention concerne également d'éventuelles modifications supplémentaires qui permettent un ciblage spécifique de ces molécules, ainsi que des procédés d'utilisation desdites MPPTs pour le traitement du cancer et d'autres maladies.
Protox Therapeutics Incorporated
Smart & Biggar
LandOfFree
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