C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 9/00 (2006.01) A61K 38/43 (2006.01) A61K 47/48 (2006.01) A61P 35/00 (2006.01) C07K 14/415 (2006.01) C07K 16/30 (2006.01) C07K 19/00 (2006.01) C12N 15/09 (2006.01) C12P 21/00 (2006.01) G01N 33/543 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2438143
The present invention concerns methods of reducing the antigenicity of a proteinaceous compound while maintaining the compounds biological activity, as well as proteinaceous compositions with biological activity but reduced antigenicity. These methods and compositions have significant benefits to a subject in need of such compounds and compositions. Also included are modified toxin compounds that are truncated and/or possess reduce antigenicity. Such designer toxins have therapeutic, diagnostic, and preventative benefits, particularly as immunotoxins. Methods of treating cancer using these immunotoxins are provided.
L'invention concerne des procédés visant à réduire l'antigénicité d'un composé protéinique tout en maintenant l'activité biologique du composé, ainsi que des compositions protéiniques présentant une activité biologique mais une antigénicité réduite. Ces procédés et compositions sont bénéfiques chez un sujet nécessitant de tels composés et compositions. L'invention concerne aussi des composés de toxines modifiées qui sont tronquées et/ou possèdent une antigénicité réduite. Ces toxines mises au point sont utiles en thérapie, dans le diagnostic et la prévention, notamment comme immunotoxines. Des traitements de cancers utilisant ces immunotoxines sont également décrits.
Cheung Lawrence
Rosenblum Michael G.
Borden Ladner Gervais Llp
Research Development Foundation
LandOfFree
Modified proteins, designer toxins, and methods of making... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Modified proteins, designer toxins, and methods of making..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Modified proteins, designer toxins, and methods of making... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1377766