A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/20 (2006.01) A23G 3/00 (2006.01) A23G 3/04 (2006.01) A61J 3/06 (2006.01) A61J 3/10 (2006.01) A61K 9/00 (2006.01) A61K 9/24 (2006.01) A61K 9/28 (2006.01) B30B 11/08 (2006.01) B30B 11/34 (2006.01) B30B 15/30 (2006.01) A61K 9/50 (2006.01)
Patent
CA 2461659
A dosage form comprises: (a) a core comprising at least one active ingredient; and (b) a molded shell which surrounds the core, wherein the shell provides a predetermined time delay of greater than one hour for the onset of dissolution of the active ingredient upon contacting of the dosage form with a liquid medium and the delay is independent of the pH of the liquid medium. The weight of the shell may be at least 50 percent of the weight of the core, and the shell may have a thickness of about 500-4000 microns, or be substantially free of pores having a diameter of 0.5 to 5 microns.
L'invention concerne une forme pharmaceutique comprenant: (a) un noyau contenant au moins une substance active; et (b) une coque moulée qui entoure le noyau, la coque conférant un temps prédéterminé supérieur à une heure pour le commencement de la dilution de la substance active lors du contact de la forme pharmaceutique avec un milieu liquide et ce temps dépendant du pH du milieu liquide. Le poids de la coque peut être d'au moins 50 % du poids du noyau, et la coque peut avoir une épaisseur d'environ 500-4000 microns ou être sensiblement exempte de pores d'un diamètre de 0.5 à 5 microns.
Lee Der-Yang
Li Shun-Por
Parikh Narendra
Sowden Harry S.
Thomas Martin
Mcneil-Ppc Inc.
Smart & Biggar
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