Modified release formulation of memantine

A - Human Necessities – 61 – K

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Details

A61K 9/22 (2006.01) A61K 31/13 (2006.01)

Patent

CA 2569015

The present invention provides pharmaceutical compositions given once daily containing at least one therapeutically active ingredient selected from the group consisting of memantine and a pharmaceutically acceptable salt of memantine, and a pharmaceutically acceptable polymeric matrix carrier. The dosage forms of the invention sustain the release of the therapeutically active agent from about 4 to about 24 hours when said dosage form is exposed to aqueous solutions. Following entry of said form into a use environment, wherein said dosage form has a dissolution rate of more than about 80% after passage of about 6 hours to about 12 hours following said entry into said use environment.

L'invention concerne des compostions pharmaceutiques administrées une fois par jour et renfermant au moins un ingrédient actif sur le plan thérapeutique sélectionné dans le groupe comprenant de la mémantine et un sel acceptable sur le plan pharmaceutique de la mémantine et un excipient de matrice polymère acceptable sur le plan pharmaceutique. Les formes galéniques selon l'invention soutiennent la libération de l'agent actif sur le plan thérapeutique entre environ 4 et 24 heures quand la forme galénique est exposée à des solutions aqueuses, suite à l'entrée de la forme dans le milieu d'utilisation, la forme galénique ayant une vitesse de dissolution supérieure à environ 80 % après le passage compris entre environ 6 heures et environ 12 heures suite à l'entrée dans le milieu d'utilisation.

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