Modified release oral pharmaceutical composition containing...

A - Human Necessities – 61 – K

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A61K 31/60 (2006.01) A61K 9/16 (2006.01) A61K 9/50 (2006.01)

Patent

CA 2240281

Modified release pharmaceutical composition and method for the treatment of inflammatory bowel diseases (IBD) such as Crohn's disease and Colitis Ulcerosa, said compositions comprising as active the ingredient 5-aminosalicyclic acid (5-ASA), and being adapted for modified and targeted release so as to obtain a clinically important localized effect profile of 5-ASA by means of releasing an appropriate amount of 5-ASA in both the small and large bowel.

On décrit une composition pharmaceutique à libération modifiée, et un procédé de traitement des maladies intestinales inflammatoires telles que la maladie de Crohn et la colite ulcéreuse. Cette composition comprend, en guise d'ingrédient actif, 5-ASA (acide 5-aminosalicylique) et elle est conçue pour une libération modifiée et ciblée, afin de produire un profil d'effet localisé cliniquement important du 5-ASA, par la libération de celui-ci en quantité appropriée tant dans l'intestin grêle que dans le gros intestin.

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