Modified release pharmaceutical compositions on the basis of...

A - Human Necessities – 61 – K

Patent

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Details

A61K 9/20 (2006.01) A61K 9/16 (2006.01) A61K 31/366 (2006.01)

Patent

CA 2613403

Novel modified release pharmaceutical composition comprising at least one active agent(s); a polymer system in an amount less than about 80% w/w of the composition comprising at least two swellable pH independent polymers wherein at least one is hydrophilic; optionally other pharmaceutically acceptable excipients is provided. Process for preparation of such compositions and methods of using them is also provided. The compositions are formulated into suitable dosage forms that provide therapeutic concentrations of active agent for extended periods of time.

L'invention concerne une nouvelle composition pharmaceutique à libération modifiée comprenant au moins un agent actif; un système polymère en quantité inférieure à environ 80% en poids de la composition comprenant au moins des deux polymères dilatables à pH indépendant, l'un d'eux au moins étant hydrophile; et éventuellement d'autres excipients pharmaceutiquement acceptables. L'invention concerne également un procédé de préparation desdites compositions et des procédés d'utilisation de ces compositions, celles-ci étant formulées sous forme de dosages appropriés fournissant des concentrations thérapeutiques d'agent actif sur des périodes étendues.

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