Modified release ramipril compositions and uses thereof

Details Modified release ramipril compositions and uses thereof Modified release ramipril compositions and uses thereof

A - Human Necessities

61

K

A61K 9/22 (2006.01) A61K 31/403 (2006.01)

Patent

CA 2730561

The invention relates to a modified release pharmaceutical composition comprising ramipril or pharmaceutically acceptable salts thereof and pharmaceutically acceptable excipient(s) wherein pharmaceutical composition is bioequivalent to conventional immediate release formulation of ramipril administered twice daily. The invention further relates to a modified release pharmaceutical composition comprising: an immediate release component comprising ramipril or pharmaceutically acceptable salts thereof and a modified release component comprising ramipril or pharmaceutically acceptable salts thereof. The invention further relates to the process for the preparation of modified release pharmaceutical composition of ramipril.

Cette invention concerne une composition pharmaceutique à libération modifiée comprenant du ramipril ou un de ses sels pharmaceutiquement acceptables et un ou des excipients pharmaceutiquement acceptables, ladite composition pharmaceutique étant biologiquement équivalente à une formulation de ramipril à libération immédiate classique, administrée à raison de deux fois par jour. L'invention concerne, en outre, une composition pharmaceutique à libération modifiée comprenant : un composant à libération immédiate comprenant du ramipril ou un de ses sels pharmaceutiquement acceptables et un composant à libération modifiée comprenant du ramipril ou un de ses sels pharmaceutiquement acceptables. L'invention concerne, en outre, le procédé de préparation d'une composition pharmaceutique de ramipril à libération modifiée.

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