Modified release solid or semi-solid dosage forms

A - Human Necessities – 61 – K

Patent

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Details

A61K 9/58 (2006.01) A61K 9/26 (2006.01) A61K 31/137 (2006.01) A61K 31/192 (2006.01)

Patent

CA 2687722

A solid or semi-solid pharmaceutical dosage form comprising non-steroidal-anti-inflammatory drugs, in particular propionic acid derivatives such as ibuprofen, along with a second active ingredient having a shorter therapeutically effective plasma concentration duration, such as phenylephrine, and methods of administering the same are provided. This method provides improved therapeutic effect, in particular pain relief along with decongestant relief, over extended time periods.

L'invention concerne une forme de dosage pharmaceutique solide ou semi-solide comprenant des anti-inflammatoires non stéroïdiens, et notamment des dérivés d'acide propionique tels que l'ibuprofène, en combinaison avec un second ingrédient actif présentant une plus courte durée de concentration plasmatique thérapeutiquement efficace, tel que la phényléphrine, ainsi que des procédés d'administration de cette forme pharmaceutique. Le procédé permet d'obtenir un meilleur effet thérapeutique, notamment en termes d'atténuation de la douleur et de décongestionnement, pendant des périodes prolongées.

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