A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/26 (2006.01) A61K 9/14 (2006.01)
Patent
CA 2611938
The invention relates to a multiparticulate modified release composition that, upon administration to a patient, delivers ticlopidine in a bimodal, multimodal or continuous manner. The multiparticulate modified release composition comprises a first component and at least one subsequent component, the first component comprising a first population of active ingredient containing particles and the at least one subsequent component comprising a second population of active ingredient containing particles. The invention also relates to a solid oral dosage form containing such multiparticulate modified release composition, and to methods for inhibiting platelet aggregation, inhibiting blood clotting, and reducing risk of stroke in a patient.
Cette invention se rapporte à une composition à diffusion modifiée multiparticulaire qui, une fois administrée à un patient, diffuse de la ticlopidine de manière bimodale, multimodale ou continue. La composition à diffusion modifiée multiparticulaire comprend un premier composant et au moins un composant secondaire, le premier composant comprenant une première population d~ingrédients actifs contenant des particules et au moins un composant secondaire comprenant une seconde population d~ingrédients actifs contenant des particules. Cette invention a également trait à une forme de dosage oral solide contenant cette composition à diffusion modifiée multiparticulaire et aux méthodes d~inhibition de l~agrégation plaquettaire, d~inhibition de la coagulation du sang et de réduction du risque d~accident cérébrovasculaire chez un patient.
Christensen Bruce J.
Devane John
Fanning Niall
Jenkins Scott
Liversidge Gary
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Christensen Bruce J.
Elan Corporation Plc
Elan Pharma International Limited
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