Modified saccharides, conjugates thereof, and their manufacture

Details Modified saccharides, conjugates thereof, and their manufacture Modified saccharides, conjugates thereof, and their manufacture

C - Chemistry, Metallurgy

07

H

C07H 13/12 (2006.01) A61K 39/095 (2006.01) A61K 39/385 (2006.01) A61P 31/04 (2006.01) A61P 37/04 (2006.01) C07H 7/00 (2006.01) C07H 11/04 (2006.01) C07H 13/02 (2006.01) C07K 2/00 (2006.01) C07K 14/195 (2006.01) C07K 14/34 (2006.01) C08G 79/04 (2006.01)

Patent

CA 2497167

Saccharide-protein conjugates having a new type of linker are described. The conjugates comprising the new linker are prepared from modified saccharides comprising a moiety of the formula (I): -A-N(R1)-L-M wherein: A is a bond, - C(O)- or -OC(O)-; Rl is selected from H or C1-C6 alkyl; L is a C1-C12 alkylene group; and M is a masked aldehyde group. The new linker is especially useful for preparing conjugates of Neisseria meningitidis serogroup A saccharide. Conjugates having this new linker have improved immunogenicity compared to other types of conjugates.

L'invention concerne des conjugués de saccharide-protéine ayant un nouveau type de lieur. Les conjugués comprenant le nouveau lieur sont préparés à partir de saccharides modifiés comprenant une fraction de la formule (I) : -A-N(R?1¿)-L-M, dans laquelle : A représente une liaison, -C(O)- ou -OC(O)-; Rl est choisi entre H ou alkyle C¿1?-C¿6 ?; L représente un groupe alkylène C¿1?-C¿12 ?; et M représente un groupe aldéhyde masqué. Le nouveau lieur est particulièrement utile à la préparation de conjugués de <i>Neisseria meningitidis</i> saccharide du sérogroupe A. Les conjugués ayant ce nouveau lieur présentent une immunogénicité améliorée comparés à d'autres types de conjugués.

Affiliated with

Also associated with

Rating

Modified saccharides, conjugates thereof, and their manufacture does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Modified saccharides, conjugates thereof, and their manufacture, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Modified saccharides, conjugates thereof, and their manufacture will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-2065028