Modified sialyl lewis x compounds

Details Modified sialyl lewis x compounds Modified sialyl lewis x compounds

C - Chemistry, Metallurgy

12

P

C12P 19/26 (2006.01) A61K 31/70 (2006.01) A61K 38/02 (2006.01) A61K 39/385 (2006.01) C07H 3/06 (2006.01) C07H 13/04 (2006.01) C07H 15/04 (2006.01) C07H 19/10 (2006.01) C07H 19/20 (2006.01) C07K 2/00 (2006.01) C12P 19/44 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2110797

The present invention is drawn to methods for the synthesis of sialyl Lewis x derivatives modified at the C-2 and/or C-G position of G1cNAc employing chemoenzymatic synthesis. The derivatives find use in the treatment and prevention of diseases.

Cette invention concerne des procédés permettant d'effectuer la synthèse de dérivés de Lewisx au sialyl modifiés en position C-2 et/ou C-6 de GlcNAc à l'aide de la synthèse chimio-enzymatique. Ces dérivés peuvent être utilisés dans le traitement et la prévention des maladies.

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