C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/62 (2006.01) A61K 38/17 (2006.01) A61K 47/48 (2006.01) C07K 14/47 (2006.01) C07K 14/71 (2006.01)
Patent
CA 2668932
The invention relates to modified soluble FGF receptor Fc fusions comprising a fusion of a soluble fragment or domain of the FGF receptor part (targeting or binding moiety) with an Fc region of an immunoglobulin part (effector function moiety), having improved biological activity including ADCC/CDC activities, compositions containing them, and method of producing such modified soluble FGF receptor Fc fusion molecules.
L'invention porte sur des fusions de Fc de récepteur de FGF soluble modifié, comprenant une fusion d'un fragment ou domaine soluble de la partie de récepteur de FGF (fraction de ciblage ou de liaison) avec une région Fc d'une partie immunoglobuline (fraction de fonction effectrice), ayant une activité biologique améliorée comprenant les activités ADCC/CDC, sur des compositions les contenant et sur un procédé de fabrication de telles molécules de fusion de Fc de récepteur de FGF soluble modifié.
Blanche Francis
Cameron Beatrice
Nesbit Mark
Nicolazzi Celine
Sordello Sylvie
Aventis Pharma S.a.
Centelion
Robic
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