Modified steroid hormones for gene therapy and methods for...

C - Chemistry – Metallurgy – 12 – N

Patent

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C12N 15/12 (2006.01) C07K 14/72 (2006.01) C12N 15/63 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2223717

The present invention provides mutated proteins of steroid hormone receptors. These mutated proteins are useful as gene medicines. In particular, these mutated proteins are useful for regulating expression of genes in gene therapy. In addition, the present invention provides plasmids encoding for the desired mutated steroid hormone receptor proteins, as well as cells transfected with those plasmids.

Protéines mutées de récepteurs d'hormones stéroïdes. Ces protéines mutées sont utiles comme médicaments géniques. En particulier, ces protéines mutées sont utiles pour réguler l'expression des gènes en thérapie génique. De plus, l'invention concerne des plasmides codant les protéines réceptrices des hormones stéroïdes mutées voulues, ainsi que les cellules transfectées par ces plasmides.

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