Modified tcf

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/18 (2006.01) C07K 14/475 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2130561

2130561 9414845 PCTABS00032 Modified TCF in which amino-acid residue(s) of the wild-type TCF responsible for glycosylation is (are) substituted or deleted so that at least one N-linked oligosaccharide chain is removed. The modified TCF have longer biological half-lives without loss of its biological activities. The modified TCFs are therapeutically important as agents for liver diseases or as anti-cancer drugs.

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