Modified therapeutic agents

Details Modified therapeutic agents Modified therapeutic agents

A - Human Necessities

61

K

A61K 47/48 (2006.01)

Patent

CA 2536795

The invention provides a modified therapeutic agent, said modified agent comprising three or more membrane binding elements with low membrane affinity covalently associated with the agent which elements are capable of interacting independently and with thermodynamic additivity, with components of cellular or artificial membranes exposed to extracellular fluids wherein at least two membrane binding elements are lipophilic elements, which may be aliphatic acyl groups, which may be selected from the list consisting of Myristoyl, Decanoyl or Hexanoyl.

L'invention concerne un agent thérapeutique modifié qui comprend au moins trois éléments de liaison aux membranes présentant une faible affinité pour les membranes associés par covalence à l'agent, ces éléments pouvant interagir de manière indépendante et avec une additivité thermodynamique, avec des composants de membranes cellulaires ou artificielles exposés à des liquides extracellulaires, au moins deux éléments de liaison aux membranes étant des éléments lipophiles, qui peuvent être des groupes acyle aliphatiques pouvant être sélectionnés dans le groupe comprenant myristoyle, décanoyle ou hexanoyle.

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