Modified timp

Details Modified timp Modified timp

C - Chemistry, Metallurgy

12

N

C12N 9/64 (2006.01) A61K 38/57 (2006.01) A61P 35/04 (2006.01) C07K 14/81 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2303509

The present invention provides a novel modified TIMP wherein the NH2-terminal .alpha.-amino group thereof is modified with an electron-accepting group to substantially lose the ability to bind to a metalloproteinase.

La présente invention fournit un TIMP modifié tandis que le groupe NH2-terminal .alpha.-amino associé est modifié par un groupe accepteur d'électrons pour perdre en grande partie l'aptitude à se lier à une metalloprotéinase.

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