Modified tissue plasminogen activator

Details Modified tissue plasminogen activator Modified tissue plasminogen activator

C - Chemistry, Metallurgy

12

N

195/1.2, 195/1.2

C12N 9/72 (2006.01) A61K 38/49 (2006.01) C12N 1/16 (2006.01) C12N 1/20 (2006.01) C12N 1/21 (2006.01) C12N 5/00 (2006.01) C12N 5/10 (2006.01) C12N 9/64 (2006.01) C12N 15/00 (2006.01) C12N 15/09 (2006.01) C12N 15/12 (2006.01) C12N 15/66 (2006.01) C12P 21/02 (2006.01)

Patent

CA 1341444

A DNA construct containing a nucleotide sequence consisting essentially of a first region encoding a fibrin- binding domain and a second region positioned downstream of the first region, with the second region encoding a catalytic domain for the serine protease activity of tissue-type plasminogen activator is disclosed. The nucleotide sequence codes for a protein which has substantially the same biological activity as t-PA. The regions may be derived from genomic clones or cDNA clones of t-PA, or may be constructed by conventional DNA synthesis techniques. Expression vectors capable of directing the expression of the t-PA-like protein, and transfected or transformed cells producing such a protein, are also disclosed.

528043

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