Modified transferin-antibody fusion proteins

Details Modified transferin-antibody fusion proteins Modified transferin-antibody fusion proteins

C - Chemistry, Metallurgy

12

N

C12N 15/62 (2006.01) A01K 67/00 (2006.01) A61K 39/395 (2006.01) C07H 21/04 (2006.01) C07K 14/79 (2006.01) C07K 16/00 (2006.01) C07K 16/24 (2006.01) C07K 19/00 (2006.01) C12N 15/12 (2006.01) C12N 15/13 (2006.01) C12N 15/63 (2006.01) C12N 15/65 (2006.01) C12N 15/86 (2006.01)

Patent

CA 2495207

Modified fusion proteins of transferrin and therapeutic proteins or peptides, preferably antibody variable regions, with increased serum half-life or serum stability are disclosed. Preferred fusion proteins include those modified so that the transferrin moiety exhibits no or reduced glycosylation, binding to iron and/or binding to the transferrin receptor.

L'invention concerne des protéines hybrides modifiées de la transferrine et des protéines ou peptides thérapeutiques, de préférence des régions variables d'anticorps, avec une demi-vie sérique ou une stabilité sérique accrue. On peut citer parmi des protéines hybrides préférées celles qui sont modifiées de manière que le fragment de la transferrine ne présente pas de glycosylation ou présente une glycosylation réduite, se liant au fer et/ou se liant au récepteur de la transferrine.

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