Modified tumor necrosis factor

Details Modified tumor necrosis factor Modified tumor necrosis factor

C - Chemistry, Metallurgy

07

K

C07K 14/525 (2006.01) A61K 38/19 (2006.01) A61K 47/48 (2006.01) A61P 35/00 (2006.01) C07K 17/02 (2006.01)

Patent

CA 2277757

Modifying TNF with polyethyleneglycol (PEG) having an approximate weight average molecular weight in the range of about 10,000 to about 40,000, preferably in the range of about 20,000 to 30,000, significantly increases the circulating half-life of the TNF. As a result, lower doses of the TNF may be administered to effectively treat tumors, with fewer accompanying adverse side effects to the patient.

La modification de TNF par un polyéthylèneglycol (PEG) présentant un poids moléculaire moyen approximatif compris entre environ 20 000 et environ 40 000, et de préférence dans une fourchette d'environ 20 000 à 30 000, accroît de manière significative la demi-vie circulante du TNF. Des doses plus faibles de TNF peuvent par conséquent être administrées pour traiter efficacement les tumeurs avec moins d'effets secondaires indésirables pour le patient.

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