Modified vaccinia virus and methods for making and using the...

Details Modified vaccinia virus and methods for making and using the... Modified vaccinia virus and methods for making and using the...

C - Chemistry, Metallurgy

12

N

167/130, 195/1.2

C12N 7/01 (2006.01) A61K 39/285 (2006.01) A61K 39/295 (2006.01) C07K 14/035 (2006.01) C07K 14/11 (2006.01) C12N 15/86 (2006.01) C12N 15/863 (2006.01) A61K 39/00 (2006.01)

Patent

CA 1340624

What are disclosed are methods for modifying the genome of vaccinia virus to produce vaccinia mutants, particularly by the introduction into the vaccinia genome of exogenous DNA; modified vaccinia prepared by such methods; certain DNA sequences and unmodified and genetically modified microorganisms involved as intermediates in such methods; and methods for infecting cells and host animals with such vaccinia mutants to provoke the amplification of exogenous DNA and proteins encoded by the exogenous DNA, including antigenetic proteins, by said cells and host animals.

418557

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