Modified vegf antisense oligonucleotides

Details Modified vegf antisense oligonucleotides Modified vegf antisense oligonucleotides

C - Chemistry, Metallurgy

07

H

C07H 21/00 (2006.01) A61K 31/70 (2006.01) C12N 15/11 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2239991

Disclosed are oligonucleotides complementary to VEGF-specific nucleic acid useful in reducing the expression of VEGF. Also disclosed are pharmaceutical formulations containing such oligonucleotides useful for treating various disorders associated with neovascularization and angiogenesis.

La présente invention concerne des oligonucléotides complémentaires de l'acide nucléique spécifique du VEGF, convenant particulièrement à la réduction de l'expression du VEGF. L'invention concerne également des formulations pharmaceutiques contenant de tels oligonucléotides convenant particulièrement au traitement de divers troubles associés à une néovascularisation et une angiogénèse.

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